Canine Health Foundation Grant #02653-A

Abstract: Atopic dermatitis (AD) is very common in dogs and children. AD is affected by complex and yet incompletely understood interactions between many factors such as environment, different types of white blood cells, and immunological factors. Chemokines are one of the factors that are used to modulate the immune system, leading to AD. Specific inflammatory chemokines were chosen for this study based on their relevance to AD from previously published studies in human and veterinary medicine. This study will evaluate the levels of these chemokines in blood, exosomes (a small pouch from cells that is used for communication between cells via blood), and skin of dogs with AD. In addition, the investigators will look for a correlation between the levels of these chemokines and severity of AD with a long-term goal to find a potential tool for monitoring and treating AD in dogs and humans.

Publications: None at this time.

Presentations: None at this time

End Year 1 Report to Grant Sponsor from Investigator (1/14/2020): We have completed the recruitment of the dogs and we are starting the laboratory component of the study.

Mid Year 2 Report to Grant Sponsor from Investigator (6/30/2020): Currently, we have started the processing of the skin and blood samples. We have completed the skin extraction and looking at blood extraction. We are planning to start the sample processing in the next 1-2 months and complete the study by the end of the year.